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September 1, 1951


Author Affiliations


From the Allergy Research Laboratory, Department of Medicine, Northwestern University Medical School, and Passavant Memorial Hospital.

JAMA. 1951;147(1):40-41. doi:10.1001/jama.1951.73670180001010

In view of the fact that the corticotrophic hormone (ACTH) is a protein, it is not surprising that hypersensitivity reactions to it would be encountered. Our early work on the repeated use of corticotrophin to prevent anaphylactic reactions in guinea pigs sensitized to horse serum indicated that the animals were being sensitized to corticotrophin. Our first experience with human sensitivity to corticotrophin is summarized in the following case report.

REPORT OF A CASE  F. J., a woman, 60, was admitted to Passavant Memorial Hospital in August, 1950, under the service of one of us (E. B.). Her major complaint was a crippling rheumatoid arthritis of about 20-years' duration. Cortisone was administered for 12 days, with some improvement in the arthritic symptoms. Because the improvement was not considered adequate, a course of corticotrophin therapy was planned. An injection of 25 mg. of corticotrophin (Armour) was followed within five minutes by alarming