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September 29, 1951

Patterns of Disease on a Basis of Physiologic Pathology

JAMA. 1951;147(5):532. doi:10.1001/jama.1951.03670220172033

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This book reflects the recent trend of integrating several originally separated disciplines. In this instance a treatise developed from lectures on pathology to medical students covers as a unit many aspects of clinical medicine. It is based on the principle of discussing the patterns of diseases as a whole and tracing them step by step through biochemical changes, altered function, altered anatomy, and final outcome. Furthermore, the significance of the compensatory mechanisms stimulated by disease is emphasized in the clinical and pathological picture. Thus, anatomic and clinical pathology are interwoven with physiology and clinical symptomatology.

In the first part, which would correspond to general pathology, the passive changes in disease, represented by disturbances of nutrition and peripheral circulation, are discussed, followed by a broad analysis of reactive changes to injury, including all aspects of the problem of inflammation. Pigmentation, degeneration, and tumors are then discussed. Following is a discussion of

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