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October 6, 1951


JAMA. 1951;147(6):578. doi:10.1001/jama.1951.03670230044015

In 1948 it was shown by Lewis1 and her associates of Wistar Institute, Philadelphia, that, when tissues from sarcoma-immune rats are minced with sarcoma grafts, the only organ that inhibits growth of the graft is the adrenal gland. Subsequent tests with the adrenals of normal rats showed a similar inhibition. The conclusion was drawn that graft inhibition was due to the action of one or more of the normal adrenal hormones. Tests were therefore made of the oncolytic action of epinephrine.2

Inbred albino rats and native tumors that were 100% transplantable were used, with four types of procedure: 1. Implantation of minced tissue to which epinephrine had been added. The epinephrine used was in the form of a sterile solution containing 1 mg. of epinephrine per cubic centimeter of isotonic sodium chloride solution, to which 0.1% sodium bisulfate and 0.5% chlorobutanol were added as preservatives. 2. Intratumor injection