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October 20, 1951


Author Affiliations


From the Department of Surgery, Union Memorial Hospital (Dr. Curtis and Dr. Rose), and the Biological Research Laboratories of Hynson, Westcott & Dunning, Inc. (Dr. Brewer).

JAMA. 1951;147(8):741-743. doi:10.1001/jama.1951.03670250033009

In a previous publication in 1944, two of us (R. M. C. and J. H. B.)1 first advocated the use of a partially hydrolized casein in the local treatment of burns and wounds, and, to date, approximately 500 patients have been treated with this preparation. Early investigations using human serum and plasma, bovine serum and plasma, and human and bovine placental serum led us to believe that the ideal type of local therapy for burns would consist of a readily available inexpensive protein which would closely resemble human plasma protein or its basic amino acids, to which the human body would show no signs of sensitivity and which would not be toxic to tissue cells. After an exhaustive study of the proteins available, the most satisfactory preparation was found to be one made from casein. It was found that casein could be prepared in combination with other materials to