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October 20, 1951


Author Affiliations

New York

From the Bureau of Tuberculosis, New York City Department of Health.

JAMA. 1951;147(8):753-755. doi:10.1001/jama.1951.73670250005011b

The literature in the past few years has emphasized the more recent interpretations of pulmonary calcifications, both parenchymal and hilar. The more widespread use of the Mantoux test, with the increase in negative reactors, revealed the fallacy of considering all the lesions tuberculous. More attention given the history, physical examination and laboratory findings results in the discovery cf pathological findings simulating tuberculosis but of other etiology. The commonest are the fungus infections, namely, coccidioidomycosis and histoplasmosis. In the presence of negative tuberculin tests, these two diseases must be included in differential diagnosis regardless of the patient's age or geographical location.

In this report we are concerned with histoplasmosis, which is no longer considered a tropical disease. The incidence of histoplasmosis has increased generally in temperate and subtropical areas. Statistics show that males are more often affected, and that persons of all ages are susceptible although more cases appear in children.