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November 17, 1951

HOMOLOGOUS SERUM HEPATITIS: CASE FOLLOWING ADMINISTRATION OF IRRADIATED HUMAN MUMPS IMMUNE SERUM

Author Affiliations

Portland, Ore.

From the Department of Internal Medicine, University of Oregon Medical School.

JAMA. 1951;147(12):1138-1139. doi:10.1001/jama.1951.73670290007011e
Abstract

The hazard of the administration of biologic preparations parenterally has been demonstrated by the recent reports1 of several cases of homologous serum hepatitis following the use of irradiated human plasma. The following is a report of a case of homologous serum hepatitis which resulted from the administration of irradiated human mumps immune serum.

Mumps immune serum was first used by Hess2 in 1915 and has been used sporadically since that time with equivocal results. Beeson and associates3 and Neefe4 have published the only reports of hepatitis following it use; the cases reported by the former occurred in an army hospital in World War II, and a single case was reported by the latter in 1946.

REPORT OF CASE  A 43-year-old white man received 40 cc. of irradiated human mumps immune serum for prophylactic purposes on June 10, 1950, because his son, aged 4, had contracted mumps.

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