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November 17, 1951

UNUSUAL REACTION TO AUREOMYCIN

JAMA. 1951;147(12):1141. doi:10.1001/jama.1951.73670290010011h

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Abstract

The administration of aureomycin has been reported to be quite free of serious toxic reactions. Gastrointestinal symptoms are quite disturbing to the patient, but are not dangerous. A case of reaction to aureomycin in which a shock-like state was observed is reported.

REPORT OF CASE  Mrs. H. H., aged 36, was seen on Oct. 12, 1950, complaining of pain in the right chest, cough, nasal obstruction and discharge, and painful swelling of the right foot. Examination showed tenderness over both antrums, scattered rhonchi in both lung fields, and interdigital dermatophytosis of both feet, with secondary infection of the right foot. The patient had a history of chronic sinusitis, with repeated exacerbations during respiratory infections. Aureomycin, 250 mg. every four hours, was ordered, and codeine was prescribed for the pain.The patient took the drug for three days, making a total of 3.75 gm. of aureomycin. At this time nausea and

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