This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
John McMichael, professor of medicine in the University of London at the Post-Graduate School of London and a pioneer in cardiac catheterization, in this small monograph summarizes recent studies, by cardiac catheterization, on heart failure and its treatment. The assembled data are unchallenged, but their interpretations are still the subject of debate.
In the chapter on "General Ideas on Heart Failure," he discusses the differences in adaptation existing in the various types of chronic heart failure, especially in terms of cardiac output.
"The Behavior of the Failing Heart" is an account of Starling's Law of the Heart as interpreted in man from McMichael's own work. Effects of transfusion and venesection are discussed.
Chapters 3 and 4 deal with the mechanism of action and the therapeutic uses of aminophylline (theophylline ethylenediamine), digitalis, and strophanthus, based chiefly on the author's experiences with intracardiac catheterization.
In the final chapter, a summary of suggested
Pharmacology of the Failing Human Heart. JAMA. 1951;147(12):1183. doi:10.1001/jama.1951.03670290091046
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: