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December 8, 1951


JAMA. 1951;147(15):1457. doi:10.1001/jama.1951.03670320057019

According to Lewis and Aptekman1 of the Wistar Institute, Philadelphia, atrophying sarcoma tissue may be antigenic and serve to protect the host against growth of subsequently implanted viable homologous sarcoma tissue. Their experiments were made on young adult rats of a strictly inbred strain and a 100% transplantable sarcoma originating in that strain.

Material for their "vaccination" tests was obtained from 10 to 11-day-old sarcoma transplants between the shoulders on the backs of rats. These tumors had attained a size of about 50 × 20 × 18 mm. The large blood vessels that supplied the tumors were located by means of a bright light directed through the skin, and then ligated. The tumors were then drawn into a fold of skin and secured by a clamp; the fold was then sewed off to form a permanent pocket.

Material removed from these pockets two to four days later was of