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December 22, 1951


Author Affiliations

Durham, N. C.

From the Department of Surgery, The Duke University School of Medicine.

JAMA. 1951;147(17):1655. doi:10.1001/jama.1951.73670340004010c

Recent studies conducted by us have revealed a reduction in the external secretion of the pancreas after vagotomy performed for peptic ulcer, and marked reduction in both volume and enzyme output of pancreatic juice when a patient is under the influence of a parasympatholytic drug, such as methantheline (banthine®) bromide.1

In addition, Ripstein2 has reported a reduction in mortality from 72% to 24% by preliminary vagotomy in dogs in which acute pancreatitis was produced by injection of bile and trypsin into the pancreatic duct followed by ligation of the duct. In addition, we have succeeded in the prevention of pancreatitis by use of banthine® in dogs that had pancreatic duct ligation followed by a pancreatic stimulant, such as secretin or pilocarpine. Pancreatitis occurred in every instance in a similar group of animals that did not receive banthine®. Experimental and clinical evidence would suggest that human pancreatitis in many