[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.204.191.0. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Other Articles
December 22, 1951

NEW AND NONOFFICIAL REMEDIES

JAMA. 1951;147(17):1668. doi:10.1001/jama.1951.73670340017012a

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

Methimazole.—  Tapazole (Lilly).— 1-Methyl-2-mercaptoimidazole.—C4H6N2S.—M.W. 114.17.—The structural formula for methimazole may be represented as follows:

Actions and Uses.—  Methimazole is similar in indications and uses to propylthiouracil, but it is perhaps twenty times as potent. The side-effects are also similar to those of propylthiouracil, and have included skin rashes, urticaria, joint pains, and agranulocytosis.

Dosage.—  Initially, 5 to 10 mg. should be given three times a day. After the hyperthyroidism is controlled, which may require 30 to 60 days, a maintenance dose of 5 to 10 mg. daily may be expected to keep the disease under control. While protracted treatment may finally extinguish the disease, the preferred course at present is to perform a thyroidectomy as soon as the disease is controlled.

Tests and Standards.—  Physical Properties: Methimazole is a white to buff, crystalline powder which has almost no taste and a very faint odor.

First Page Preview View Large
First page PDF preview
First page PDF preview
×