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December 29, 1951


Author Affiliations

1834 Pine St., Philadelphia 3.

JAMA. 1951;147(18):1777. doi:10.1001/jama.1951.03670350057026

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To the Editor:  —The report in The Journal of Nov. 17, 1951, by James A. Greene, entitled "Pituitary Dwarfism," presented conclusions which must be considered controversial in the light of our present knowledge of growth mechanisms and the role of the pituitary gland. The growth-promoting properties of a "pituitary extract" (origin, potency, and other pertinent factors unstated) used in these studies have never before been duplicated in humans to my knowledge. Results in the treatment of dwarfism secondary to hypopituitarism with pure crystalline somatotropin have been uniformly discouraging. Lewis, Klein, and Wilkins (J. Clin. Invest. 29:460 [April] 1950) failed to obtain growth, weight gain, nitrogen retention, or rise in serum inorganic phosphorus in a dwarf (probably panhypopituitary) and in a cretin but did note malaise, fever, anorexia, and negative nitrogen balance. Escamilla and Bennett (J. Clin. Endocrinol. 11:221 [Feb.] 1951) obtained similar results in a pituitary dwarf.In

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