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March 1, 1952


JAMA. 1952;148(9):747. doi:10.1001/jama.1952.02930090057017

Johnson and co-workers1 have reported that the administration of cortisone following ligation of a branch of the coronary artery in dogs results in a pronounced decrease in the size of the myocardial infarct produced. In their experiment the anterior descending branch of the left coronary artery was ligated just below the origin of the circumflex branch in 14 dogs. Seven of these animals were given cortisone in doses of 12.5 to 20 mg. twice daily for 14 to 22 days, starting on the day of ligation. The remaining seven received no cortisone. Two or three weeks after operation the hearts of all the animals were examined grossly and microscopically. In the cortisonetreated animals the infarcts were approximately 1/7 the size of those in the control animals. Microscopically, the infarcts in the cortisone-treated animals showed a decrease in fibroblastic proliferation and a sharp line of demarcation between the damaged and