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Article
May 10, 1952

TRANSMISSION OF LEUKEMIC AGENT FROM PARENTS TO OFFSPRING IN MICE

Author Affiliations

Veterans Administration Hospital 130 West Kingsbridge Rd. Bronx 68, N. Y.

JAMA. 1952;149(2):187. doi:10.1001/jama.1952.02930190089028

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Abstract

To the Editor:—  In describing the results of recent studies on mouse leukemia carried out in this laboratory (J. A. M. A.148:746 [March 1] 1952) experiments referring to the transmission of the leukemic agent from parents to offspring were designated as "tests... of the possibility of transplacental transmission of the leukemic agent." This statement referred to a series of experiments in which, as a result of the inoculation of the leukemic agent into suckling infant mice of a nonleukemic line, in not only the inoculated animals did leukemia develop but later on also in 48% of their untreated offspring (Gross, L.: Proc. Soc. Exper. Biol. & Med.78:342, 1951). These experiments suggest that the leukemic agent is transmitted from the inoculated parents to their offspring; the question remains open, however, how such transmission may occur.The possibility of transmission of the leukemic agent from mothers to their

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