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May 17, 1952


JAMA. 1952;149(3):278-279. doi:10.1001/jama.1952.02930200064013

Recent advances in the laboratory seem to offer encouragement that preventive measures against poliomyelitis may soon be forthcoming. Identification of the poliomyelitis virus heretofore has been contingent on three criteria: host range, neutralization tests, and cross protection tests. These tests have led to the recognition of at least three broad types of poliomyelitis virus, the Lansing, the Brunhilde, and the Leon strains. Complement-fixation tests have been described, but the complement antibody response appears to be transient in both animal and human infections; thus a positive test would suggest a current or recent infection while a negative one would indicate either no exposure or infection in the remote past.1 Recently developed methods of growing the poliomyelitis virus in cultures of neural and non-neural tissues both of human beings and of laboratory animals2 provide a means for recognition in vitro of the virus and for a study of its cytopathogenic