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June 14, 1952


JAMA. 1952;149(7):665. doi:10.1001/jama.1952.02930240043016

For several decades rhinologists and endocrinologists have been aware of a relation between thyroid deficiency and nasal disease. That the connection between the thyroid gland and the nasal cavity is real and not merely fortuitous has been confirmed on a number of occasions by various investigators. Recently Proetz,1 impressed by the frequency with which hypothyroidism suggested itself as a causative factor in nasal disease and headache, described his experiences with 130 patients, all of whom were selected for study because the diagnosis of hypothyroidism was reasonably certain, confusing complications did not exist, and response to thyroid extract therapy was demonstrable. The average basal metabolic rate of the pretreated group varied from —17.5% to—21.6%

In these patients deficient in thyroid hormone, neither red nor pale coloration of the nasal mucous membrane was pathognomonic, for such hues are also characteristic of other nasal disorders. Although colds were not severe, they were interminable;