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June 14, 1952


JAMA. 1952;149(7):666. doi:10.1001/jama.1952.02930240044018

Measurement of the volume of the extracellular fluid could be of importance clinically if the methods presently used were simple and accurate enough. The standard method of determining the extracellular fluid is based on measuring the inulin space as suggested by Gaudino and associates.1 Since inulin is rapidly excreted in the urine, a large priming dose of the material must be given. An intravenous infusion of inulin is then administered at a constant rate for about six hours. This length of time is necessary to insure a uniform distribution of the inulin in the extracellular fluid. Recently Deane and co-workers2 confirmed the observations of others that intravenously administered sucrose is not metabolized in man (though it is in the dog) and found that the volume of distribution of sucrose is the same as that of inulin. But since sucrose has a much smaller molecular weight than inulin (342