The problems posed by the etiology and treatment of keratosis blennorrhagica are well known. A close but indeterminate relation to gonorrhea exists in many, but not all, cases. Recently pleuropneumonia-like organisms have been suspected of being causative agents.1 Another
theory is that the disease is a nonspecific "reaction pattern" to a variety of stimuli, one of which is the Gonococcus. According to Combes, Dietrich, and Cohen,2 the consensus is that "... [keratosis blennorrhagica] is an allergic expression of a sensitized skin similar to the conception of the tuberculid reaction."
A large number of therapeutic agents have been used in keratosis blennorrhagica.3 Recently variable results have been reported with the use of antibiotics.4 In general, results have been most efficacious in cases in which there has been an active gonococcic infection.
In the following case, a prompt and apparently lasting cure was obtained with corticotropin (ACTH). Successful treatment
Myerson RM, Katzenstein L. KERATOSIS BLENNORRHAGICA SUCCESSFULLY TREATED WITH CORTICOTROPIN (ACTH): REPORT OF A CASE. JAMA. 1952;149(9):838–839. doi:10.1001/jama.1952.72930260013009f
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