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Article
February 21, 1953

TREATMENT OF LUPUS VULGARIS WITH ISONIAZID: REPORT OF TWO CASES

Author Affiliations

Cincinnati

JAMA. 1953;151(8):640-642. doi:10.1001/jama.1953.02940080040009a
Abstract

Lupus vulgaris has been treated by many methods, but not until the advent of calciferol had oral therapy been of any distinct value. Isoniazid has now appeared on the horizon, and it is believed that this drug may hold great promise in the treatment of this and allied diseases. It is not a new drug, since it was first prepared in 1912 but was not tried with any success until recently when it was used in the treatment of active tuberculosis. Inasmuch as lupus vulgaris is a true tuberculoderma, we used isoniazid in the treatment of this disease. The results and conclusions are herewith reported.

REPORT OF CASES

Case 1.—A 56-year-old woman stated that a small blemish first appeared in the center of her left cheek in 1912. This gradually enlarged, until after a number of years the forehead, both cheeks, and the entire left side of her neck were

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