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Article
July 12, 1952

UNUSUAL REACTION TO INTRAPLEURAL ADMINISTRATION OF STREPTOKINASE AND STREPTODORNASE

Author Affiliations

Coral Gables, Fla.
From the Medical Service, Veterans Administration Hospital, Coral Gables, Fla.

JAMA. 1952;149(11):1012-1014. doi:10.1001/jama.1952.72930280003009b
Abstract

Streptococcic fibrinolysin (streptokinase) and streptococcic desoxyribonuclease (streptodornase) have been found to be beneficial in treating a variety of clinical states. Their mode of action and therapeutic usefulness have been described elsewhere.1 These enzymes have been chiefly employed in the liquefaction of pleural exudates. Toxic systemic reactions caused by these substrates have been reported.2 In at least 50% of the patients treated there is a febrile reaction, with associated malaise, headache, orthopnea, and, occasionally, nausea. This generally occurs approximately four to six hours after the administration of streptokinase and streptodornase, subsiding in the ensuing 24 to 48 hours. According to the protocol furnished by the manufacturers of the drugs, these side-effects are treated symptomatically and rarely are of a nature requiring cessation of treatment. It is the purpose of this report to show that the thermal reaction may be attained by serious consequences and that the patient should be

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