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Article
August 9, 1952

MENINGITIS DUE TO PSEUDOMONAS AERUGINOSA: INTRATHECAL TREATMENT WITH STREPTOKINASE AND STREPTODORNASE AND INTRAMUSCULAR AND INTRATHECAL TREATMENT WITH NEOMYCIN

Author Affiliations

New York
From the Department of Medicine and Neurosurgery, Cornell University Medical College and the Cornell Medical and Surgical Divisions, Bellevue Hospital.

JAMA. 1952;149(15):1395-1397. doi:10.1001/jama.1952.72930320006009e
Abstract

The over-all mortality from meningeal infection with Pseudomonas aeruginosa was found by Stanley to be 68% in a review of 90 cases reported to 1947.1 The same author observed that, when the cases were divided into groups depending on whether the infection was primary in the meninges or whether it had developed secondary to foci elsewhere in the body, there was a pronounced difference in the case fatality rate. Patients in whom meningitis was the primary disease, comprised mostly of persons who were infected by lumbar punctures or after neurosurgical procedures, showed a mortality rate of 55%. Patients in whom the meningitis occurred as a complication of infection originating elsewhere in the body showed a mortality rate of 86%. From these data it is apparent that meningitis due to Ps. aeruginosa is a serious disease. Moreover, it is our opinion that published reports tend to minimize the mortality figures,

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