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May 8, 1954


JAMA. 1954;155(2):128. doi:10.1001/jama.1954.03690200040013

It is generally recognized that pancreatic fibrocystic disease is characterized by pathological changes both in the pancreas and in the respiratory system that lead to digestive disturbances and to obstructive emphysema and secondary pneumonia respectively. Recent work indicates that yet another organ system, the sweat glands, may be involved in this disease, predisposing the patient to severe salt depletion in hot weather. It further appears that this sweating abnormality in the absence of pancreatic abnormalities may be present in members of the families of patients with pancreatic fibrosis.1

Studies on the sweating mechanism in patients with pancreatic fibrocystic disease were prompted by the fortuitous observation that during a New York heat wave several babies with fibrocystic disease were admitted to the hospital with a type of heat prostration whose clinical picture did not fit any of the known mechanisms for collapse.2 The babies sweated freely and showed no

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