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To the Editor:—
It is unfortunate that so many investigators, such as Drs. Charles W. Dowden and James T. Bradbury (Eosinophil Response to Epinephrine and Corticotropin: Studies in Alcoholics and Nonalcoholics, J. A. M. A.149:725-728 [June 21] 1952) continue to use subnormal eosinopenic response to injection of epinephrine as a means of testing pituitary-adrenal function.In 1950, on the basis of animal investigations, Thorn and his associates (Recant, Hume, Forsham, and Thorn: Studies on the Effect of Epinephrine on the Pituitary-Adrenocortical System, J. Clin. Endocrinol.10:187, 1950) postulated that the hypothalamus, pituitary, and adrenal cortex are successively stimulated to produce epinephrine eosinopenia. Thorn and Forsham wrote that "... a fall of 50% or more in circulating eosinophils (after injection of epinephrine) excludes the presence of serious pituitary A.C.T.H. or adrenal cortical insufficiency," (Thorn and Forsham: Clinical Tests for Adrenal Cortical Reserve, in Progress in Clinical Endocrinology, Soskin, S.,
Kark RM. EOSINOPENIC RESPONSE TO EPINEPHRINE. JAMA. 1952;149(15):1413. doi:10.1001/jama.1952.02930320053020
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