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August 9, 1952

Untoward Reactions of Cortisone and ACTH

JAMA. 1952;149(15):1428. doi:10.1001/jama.1952.02930320068030

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The authors have been able to crowd a surprising amount of information into this short monograph, which is succinctly worded and excellently documented. The treatise first considers the physiological effects of corticotropin and cortisone and then illustrates how their physiological effects may be exaggerated into untoward reactions by treatment. The authors emphasize that treatment dosage, except in deficiency states, constitutes an unphysiological quantity of hormone, and outline the effects that may occur in various anatomic systems. The salient factors of interest are given in outline form at the head of each chapter; they are then more fully developed in the text. This handling of textual material is a definite aid to study and review. With the exception of the physiological considerations, the ideas concur with present day thought. This book is recommended as an excellent teaching and review text for medical students and physicians.

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