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To the Editor:—
Since the introduction of cytodiagnosis, carcinoma in situ has become recognized as a neoplasm of surprising frequency. Since the lesion is often found in cervical tissues that appear normal, one of the significant problems has been to secure biopsy confirmation of these lesions following initial detection with cytology. The absence of a target lesion for biopsy has indicated the need for a "ring biopsy" if histological study is to be accurate. Considerable mystery surrounds this so-called embryo cancer, since numerous reports have appeared in the literature indicating apparent spontaneous regression, especially during or following pregnancy.In an effort to secure a comprehensive expression of authoritative medical opinion concerning its character, the Dade County Cancer Institute recently prepared a questionnaire on carcinoma in situ that was mailed to leading authorities in the fields of gynecology, pathology, and cytology. Replies were received from members of the American Gynecological Society,
Ayre JE, Davis CH. CARCINOMA IN SITU. JAMA. 1952;149(17):1594. doi:10.1001/jama.1952.02930340078020
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