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September 11, 1954


Author Affiliations

University of Michigan Institute of Industrial Health Ann Arbor, Mich.

JAMA. 1954;156(2):194. doi:10.1001/jama.1954.02950020100023

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To the Editor:—  The Journal (155:737 [June 19] 1954) published an article by Bernard Straus entitled "Aplastic Anemia Following Exposure to Carbon Tetrachloride." Without in any measure challenging the reliability of the clinical and laboratory findings presented, it becomes necessary to entertain reservations that carbon tetrachloride was the prime or sole causative agent. Of all industrial solvents, carbon tetrachloride more than any other has led to substantial reports as to toxic properties. Every degree of severity of involvement has been investigated, including mild functional disorders, acute nonfatal cases, rapidly fatal cases, and fatal cases with delayed symptoms. Autopsy appraisals have been frequent. The consensus of opinion is that expressed by Browning: "There appear to be no pathognomonic blood changes associated with carbon tetrachloride intoxication." However, Browning does mention one fatal anemia in a person who had acute dilatation of the stomach with heart failure, a secondary cause being "anemia

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