• The C-reactive protein test, performed by a capillary precipitin method with the use of commercially available antiserum, was applied to 3,543 blood donors and 633 patients in 37 different disease categories. The distribution of positive reactions failed to reveal any possibilities of the test as a screening method for the detection of any one condition in mass surveys. It was not of value in detecting carriers of homologous serum jaundice or in predicting minor transfusion reactions. Patients who experienced chills after transfusions developed a positive C-reactive protein test. Serums initially negative became positive after refrigeration and storage. The test represents a type of immune reaction but is unstable and nonspecific.
Knights EM, Hutchins M, Morgan E, Ploompuu J. USE OF THE C-REACTIVE PROTEIN TEST AS A SCREENING PROCEDURE FOR BLOOD DONORS. JAMA. 1956;162(1):9–13. doi:10.1001/jama.1956.02970180011003
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