• Coma, hemiparesis, generalized convulsions, and other alarming neurological symptoms occurring post-operatively in five patients were shown to be associated with water intoxication and an unrecognized depletion of sodium. The diagnosis was verified by studies of the blood electrolytes and by the prompt clinical response to the intravenous administration of sodium chloride. The possibility of water intoxication and depletion of sodium should be considered in all patients in whom neurological disturbances develop during the first few days after operation.
Bartholomew LG, Scholz DA. REVERSIBLE POSTOPERATIVE NEUROLOGICAL SYMPTOMSREPORT OF FIVE CASES SECONDARY TO WATER INTOXICATION AND SODIUM DEPLETION. JAMA. 1956;162(1):22–26. doi:10.1001/jama.1956.02970180024007
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: