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September 1, 1956


JAMA. 1956;162(1):31-32. doi:10.1001/jama.1956.72970180001009

Subacute thyroiditis is an inflammatory disease involving the thyroid gland but associated with a systemic reaction characterized by fever and general malaise. A large number of papers upon this subject have appeared within the last decade. Recently these have been summarized in a complete review undertaken by Hazard.1 It is my purpose to describe a laboratory finding in this disease, mention of which I have not encountered in the medical literature available to me. This consists of a striking elevation of the alpha-2 component of the globulin fraction of the blood. I shall describe two cases in which this change was noted and shall attempt to explain the cause of this change, correlating it with other reported findings.

Report of Cases 

Case 1.—  A 47-year-old Caucasian man first became ill on Sept. 1, 1955. His initial symptoms were general malaise and weakness after vigorous walking. He also had a