Subacute thyroiditis is an inflammatory disease involving the thyroid gland but associated with a systemic reaction characterized by fever and general malaise. A large number of papers upon this subject have appeared within the last decade. Recently these have been summarized in a complete review undertaken by Hazard.1 It is my purpose to describe a laboratory finding in this disease, mention of which I have not encountered in the medical literature available to me. This consists of a striking elevation of the alpha-2 component of the globulin fraction of the blood. I shall describe two cases in which this change was noted and shall attempt to explain the cause of this change, correlating it with other reported findings.
Report of Cases
A 47-year-old Caucasian man first became ill on Sept. 1, 1955. His initial symptoms were general malaise and weakness after vigorous walking. He also had a
Stemmermann GN. SERUM PROTEIN CHANGES IN SUBACUTE THYROIDITIS. JAMA. 1956;162(1):31–32. doi:10.1001/jama.1956.72970180001009
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