• The direct methods of determining the concentration of acid in the stomach by aspiration, titration, and pH measurements are now supplemented by indirect methods. The patient ingests an exchange resin combined with colored or fluorescent indicators. These are liberated by acid in the stomach and can be determined in the urine. Failure of the acid-secreting cells can thus be discovered. The concentration of pepsin in the blood and urine depends on the activity of the chief cells of the gastric mucosa. Pepsin tests are therefore used to discover the varying degrees of failure of the enzyme-secreting cells.
The presence or absence of the intrinsic antianemic factor in the stomach is determined by two recent tests with radioactive cyancobalamin. Taken by mouth, it is absorbed by the intestine and excreted in the urine only if the intrinsic factor is present in the stomach.
Spiro HM. PRESENT-DAY CONCEPTS OF ANACIDITY. JAMA. 1956;161(1):9–12. doi:10.1001/jama.1956.02970010011003
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