• Surgical ablation of the hypophysis has been carried out in 79 patients with advanced cancer. The most satisfactory approach was by way of a right frontal craniotomy. It was used in 53 instances.
Most patients developed polyuria within 24 hours after a complete ablation; amenorrhea followed in the female patients, and testicular atrophy was observed in two males. Unless replacement therapy was kept up, adrenal insufficiency appeared within two to seven days and hypothyroidism within four to eight weeks.
Objective remission was obtained in 21 out of 41 cases of mammary cancer in which evaluation was possible. Generalizations proved difficult for several reasons, especially because other forms of ablative surgery had in some cases preceded the hypophysectomy and because some patients were still in remission at the time of the report. The selection of patients for hypophysectomy will remain unsatisfactory until the endocrine factors concerned are more completely determined.
Pearson OH, Ray BS, Harrold CC, et al. HYPOPHYSECTOMY IN TREATMENT OF ADVANCED CANCER. JAMA. 1956;161(1):17–21. doi:10.1001/jama.1956.02970010019005
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