• The finding of three cases of acute leukemia and one of lymphosarcoma in a family of 12 siblings prompted this study of possible causation. Since no environmental cause could be identified, the likelihood of a genetic cause was investigated by constructing a pedigree and attempting to determine the causes of death among the many relatives of the four patients. The possibility that a recessive gene was involved was especially considered because of the finding of evidences of consanguinity, including the fact that the parents were first cousins.
Johnson MJE, Peters CH. LYMPHOMAS IN FOUR SIBLINGS. JAMA. 1957;163(1):20–25. doi:10.1001/jama.1957.02970360022005
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