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Article
January 5, 1957

LYMPHOMAS IN FOUR SIBLINGS

JAMA. 1957;163(1):20-25. doi:10.1001/jama.1957.02970360022005
Abstract

• The finding of three cases of acute leukemia and one of lymphosarcoma in a family of 12 siblings prompted this study of possible causation. Since no environmental cause could be identified, the likelihood of a genetic cause was investigated by constructing a pedigree and attempting to determine the causes of death among the many relatives of the four patients. The possibility that a recessive gene was involved was especially considered because of the finding of evidences of consanguinity, including the fact that the parents were first cousins.

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