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January 5, 1957


JAMA. 1957;163(1):40-41. doi:10.1001/jama.1957.02970360042010

Studies of a group of viruses variously named (AD for "adenoid degeneration," RI for "respiratory illness," and APC for "adenoidal-pharyngeal-conjunctival") have resulted in their being classed together and called the adenoviruses at the suggestion of a group of virologists.1 This action was taken in view of the fact that certain characteristics were observed in all these viruses. All types (1) grow only in tissue cultures of certain human or simian cells, (2) produce cytopathogenic changes in such cultures, (3) are nonpathogenic for the usual laboratory animals, (4) are heat labile, (5) are filterable, (6) are resistant to antibiotics and ether, and (7) have a group-specific but not type-specific, soluble, complement-fixing antigen.2 Hilleman and co-workers3 found evidence that the RI-67 group of viruses, now known as type 4, cause a large proportion of cold-agglutinin-negative cases of primary atypical pneumonia and an acute respiratory disease (ARD) that Ginsberg and