Crystalline penicillin G has been proposed as the remedy of choice with sulfadiazine as alternate in the treatment of actinomycosis.1 The two agents have also been used in combination. Streptomycin,2 bacitracin,3 and aureomycin4 have also been reported to be efficacious. The observation that "stilbamidine" (4,4′-stilbenedicarboxyamidine) was a useful therapeutic agent for infections caused by Blastomyces dermatitidis5 prompted its use in a patient with actinomycosis resistant to prolonged administration of penicillin and sulfadiazine.
REPORT OF A CASE
A 51-year-old white man was admitted to the Veterans Administration Hospital on Jan. 4, 1951, with a mass in the left submental region that had appeared after extraction of a tooth in November, 1950. The tumor had become progressively larger. Pain in the right side of the chest and a cough had been treated by the patient's physician with aureomycin for two days. The patient lost 9 lb. (4.1
Joseph M. Miller, Perrin H. Long, Emanuel B. Schoenbach. SUCCESSFUL TREATMENT OF ACTINOMYCOSIS WITH "STILBAMIDINE". JAMA. 1952;150(1):35. doi:10.1001/jama.1952.63680010008008f