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Article
May 5, 1956

TREATMENT OF ACUTE ALCOHOLISM WITH PROMAZINE (SPARINE)

JAMA. 1956;161(1):44-45. doi:10.1001/jama.1956.02970010046013
Abstract

• Acute alcoholic intoxication in 141 instances was treated with promazine in doses ranging from 25 to 100 mg. orally every four to six hours. In the presence of vomiting the initial dose was given intramuscularly with little pain or local reaction. Nausea and vomiting were promptly checked in 89% of the patients, and symptoms of gastritis were dramatically relieved. All patients with gastric complications were able to retain fluids and nourishment within a few hours after treatment began.

Withdrawal symptoms were satisfactorily controlled in all patients who remained for the complete course of treatment, which usually required three to five days. Although 70% of the patients were also suffering from various complications, including Laennec's cirrhosis, no serious complications ascribable to the drug develop throughout the entire series. Dizziness and postural hypotension were the only side-effects encountered, and the hypotensive effect and compensatory tachycardia were less noticeable than in patients treated with chlorpromazine.

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