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September 8, 1956


JAMA. 1956;162(2):137. doi:10.1001/jama.1956.02970190053020

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To the Editor:—  With regard to reactions to meprobamate ( Kositchek, R. J.: Reactions to Meprobamate, Correspondence Section, J. A. M. A.161:644 [June 16] 1956), my colleague and I have now given this drug to more than 200 patients, including the prerelease testing that we were asked to do. We found absolutely no toxic adverse effects, except dizziness in some patients, when 400 mg. was used as a dose. We therefore now prescribe 200 mg. (1/2 tablet) to be taken after meals and before bedtime. We have never found erythema in our patients. However, we are not under any delusion on this score; we will probably get our 2% of reactions all at one time. There is hardly a useful drug on the market that does not give this small percentage of reactions. The author of the letter dramatically states that all types of antihistamines were prescribed but to

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