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Almost 50 years ago Sir Henry Dale showed that the injection of histamine into a normal animal produced symptoms essentially identical with those of anaphylactic shock. This fascinating substance has been ultimately connected with the mechanism of the allergic reaction and inflammation and with some other bodily processes. Many men have spent almost a lifetime studying phases of activity of this substance and its source, site and manner of action, release, and inactivation. In the last few years this work has been intensified, and, with newer chemical methods, isotope labeling, chromatography, and other modern techniques, progress in information about the significance of histamine has been rapid. This book constitutes a report of the papers and discussion on histamine held at a symposium in April, 1955, at the Wellcome Foundation and at the Ciba Foundation in London. The participants were outstanding investigators on this subject from many parts of the world.
Ciba Foundation Symposium Jointly with the Physiological Society and the British Pharmacological Society on Histamine. JAMA. 1956;162(2):149. doi:10.1001/jama.1956.02970190065027
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