• Chlorpromazine was administered by mouth, generally in doses of 25 mg. three or four times daily, in nine cases of intermittent acute porphyria with pain and other serious symptoms. This dosage sufficed to control the symptoms in most cases, although it did not cure established paralyses. In three of the patients a single dose of 100 mg. of chlorpromazine was followed by complete clinical remission. The first effect was a relief of the nervous symptoms, including the pain; this improvement was not correlated with any significant changes in excretion of porphyrin or porphobilinogen during the period of study. The drug appeared to interrupt a vicious cycle, after which the patient was able to regain a state of remission spontaneously. Chlorpromazine has been the most consistently effective remedy thus far available for the pain and nervous manifestations of porphyria.
Melby JC, Street JP, Watson CJ. CHLORPROMAZINE IN THE TREATMENT OF PORPHYRIA. JAMA. 1956;162(3):174–178. doi:10.1001/jama.1956.02970200022005
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