• Chlorambucil was administered by mouth in doses ranging from 5 to 30 mg. daily for five to seven weeks, so than an average course amounted to 350 mg. Thirty patients were thus treated for lymphocytic leukemias and various lymphomas. In the largest group, namely, 18 patients with chronic lymphocytic leukemia, 3 patients obtained excellent results, in that the hemoglobin level and white blood cell count returned to normal, the differential count was significantly improved, and hepatosplenomegaly and lymph node enlargement disappeared. Eight other patients of this group obtained good results in that the white blood cell count fell, the hemoglobin level rose, the differential count improved, and the liver, spleen, and lymph nodes decreased in size. Results in cases of lymphocytic lymphosarcoma and Hodgkin's disease were less encouraging. In the dosages used, chlorambucil was practically without side-effects.
Ultmann JE, Hyman GA, Gellhorn A. CHLORAMBUCIL IN TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA AND CERTAIN LYMPHOMAS. JAMA. 1956;162(3):178–183. doi:10.1001/jama.1956.02970200026006
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