The history of excretory urography has been reviewed by Braasch and Emmett.1 Sodium iodomethamate (Neo-Iopax) and iodopyracet injection (Diodrast) were the excretory urographic mediums used for many years in the United States, but these were replaced by sodium acetrizoate injection (Urokon) because of its capacity to produce urograms of better quality. In August, 1954, we were invited to assist in the investigation of a new urographic contrast medium, diatrizoate sodium (Hypaque). This medium is a highly watersoluble white crystalline solid that contains iodine (59.87%). The preparation is dispensed in ampuls containing 30 cc. of a 50% solution. In our initial investigation, we gave intravenous injections using these ampuls to 200 patients. Experience demonstrated that an injection time of three to five minutes was desirable. For each patient, the temperature, pulse rate, respiration rate, and blood pressure were recorded before and 15 minutes after an injection. In no instance was
Seedorf EE, Bradfield EO. DIATRIZOATE SODIUM, A NEW UROGRAPHIC CONTRAST MEDIUM. JAMA. 1956;162(3):192–193. doi:10.1001/jama.1956.72970200001008
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