The term "myelophthisic anemia" refers to the type of anemia that occurs in association with space-occupying lesions of the bone marrow. The case presented in this report is an example of the commonest type of space-occupying lesion that produces myelophthisic anemia— namely, metastatic carcinoma to the bone marrow. In my experience, metastatic carcinoma of the prostate produces this type of marrow dysfunction oftener than any other cancer, although cancers of the lungs, breasts, adrenals, thyroid, and urinary bladder are also prone to metastasize to bones that contain actively functioning bone marrow in the adult and may thus cause myelophthisic anemia. Other diseases that may produce changes in the blood characteristic of this type of anemia include myelosclerosis, certain chronic infectious granulomas, Hodgkin's disease, multiple myeloma, and the primary xanthomatoses. The symptoms manifested by these patients are usually referable to the primary tumor or disease or are due to the anemia
Reinhard E. COMMENT. JAMA. 1956;161(1):61–62. doi:10.1001/jama.1956.62970010013016a
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