How sulfapyridine causes acute hemolytic anemia is not known, and the reaction can only be classed as an idiosyncrasy.1 The beneficial effect of corticotropin (ACTH) on "idiopathic" acquired hemolytic anemia has been described by Dameshek,2 Gardner,3 Davidson,4 and their co-workers. Davidson and associates also noted no significant improvement when corticotropin was given to patients with congenital hemolytic anemia. Simpson and his colleagues5 reported two cases in which corticotropin appeared to produce some improvement in patients with erythroblastosis fetalis. No account of the effect of corticotropin in acquired hemolytic anemia due to a drug has come to our attention.
REPORT OF A CASE
A 51-year-old Filipino barber consulted one of us (H. L. A.) on May 21, 1951, because of a second attack of severe dermatitis repens of the right foot complicated by infection with an organism of the coli-aerogenes group and by Pseudomonas aeruginosa intertrigo
Gilbert FI, Arnold HL. FAILURE OF CORTICOTROPIN TO PREVENT ACUTE HEMOLYTIC ANEMIA DUE TO SULFAPYRIDINE. JAMA. 1952;150(2):95–96. doi:10.1001/jama.1952.63680020004007b
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