• Candida albicans infection (moniliasis) was demonstrated by culture in 59 out of 76 patients who had symptoms of vaginitis. Treatment with nystatin, inserted as tablets vaginally at bedtime, cured the moniliasis in 58 cases and failed only in one patient, who did not follow instructions. Of the two case histories given, one illustrates recovery, within two days, of a patient who had been treated for intense pruritus by various other means for several months; the other patient developed moniliasis after intensive treatment with antibiotics for pelvic inflammatory disease and recovered from moniliasis promptly after administration of nystatin. The infection recurred in 14 cases but was eradicated by a second course of treatment. Nystatin was not effective as a rule in trichomoniasis, but in moniliasis it relieved the pruritus promptly and did not cause any side-effects.
Pace HR, Schantz SI. NYSTATIN (MYCOSTATIN) IN THE TREATMENT OF MONILIAL AND NONMONILIAL VAGINITIS. JAMA. 1956;162(4):268–271. doi:10.1001/jama.1956.02970210008004
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