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May 5, 1956


JAMA. 1956;161(1):96. doi:10.1001/jama.1956.02970010098030

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To the Editor:—  Because of the widespread acceptance of the tranquilizing drug meprobamate, marketed under the names of Equanil and Miltown, I thought the following brief case report would be of interest. A 42-year-old female with insomnia, tension headaches, and other complaints of an anxiety nature was given meprobamate, 400 mg. three times a day, on March 15, 1956. After taking the third tablet she noted a feeling of warmth in the arms and thighs and on March 16 noted a widespread hemorrhagic rash on her axillas, breasts, chest, abdomen, arms, and inner thighs and legs. She continued the medication and had a temperature of 101 F (38.3 C), with hard, shaking chills and moderate edema of the legs and ankles. When seen on March 19, she had a widespread purpura involving the axillas, breasts, chest, arms, inner thighs and legs. Physical examination was otherwise not remarkable. No history was

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