• Where prolonged palliation of mammary carcinoma is indicated, especially with but not limited to extensive disease, and without regard to prior therapy, the phosphoramide drugs may be useful. Medication may be administered by various routes to effect an intratumor application, and also orally to suit the needs of the patient. The ability to use the drug on an outpatient basis, even with extensive disease, provides an economic and psychological advantage to the patient concurrent with the objective response. Hematopoietic depression occurring as a side-effect also serves as a guide in determining dosage.
Bateman JC, Carlton HN. PALLIATION OF MAMMARY CARCINOMA WITH PHOSPHORAMIDE DRUGS. JAMA. 1956;162(8):701–706. doi:10.1001/jama.1956.02970250001001
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