• Clinical impressions based on more than 1,000 administrations of promethazine in surgical patients showed that this drug is useful in anesthesiology as a sedative preoperatively, as a supplement to the milder anesthetics in producing the lighter planes of anesthesia and the hypothermic state, as a means of combating emesis and hiccups, and as a sedative postoperatively. The recommended procedure for premedication in the average case includes the intramuscular injection of 50 mg. of promethazine 120 minutes before induction, intramuscular injection of 50 mg. of meperidine 60 to 45 minutes before induction, and 0.4 mg. of either scopolamine or atropine 30 minutes before induction. The drug, with or without meperidine, has been used with excellent effect in children, and few side-effects have occurred when it has been given in usual dosages.
Sadove MS. PROMETHAZINE IN SURGERYPRELIMINARY REPORT. JAMA. 1956;162(8):712–715. doi:10.1001/jama.1956.02970250012004
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