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October 11, 1952


JAMA. 1952;150(6):605-606. doi:10.1001/jama.1952.03680060077027

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Untoward Effects of Antibiotic Therapy.—Professor Coppo, director of the University of Modena Medical Clinic, lectured on untoward effects of antibiotic therapy, especially in pulmonary disease. He classified these effects into the following nine groups, seven of which are related to antibiotic therapy in general, while the other two refer to therapy of pulmonary disease.

  1. Specific hypersensitivity to the antibiotic, as manifested by allergic dermatoses after administration of penicillin, is often witnessed.

  2. Generic intolerance to antibiotics may be of toxic nature, it may be due to Herxheimer's reaction, or it may be of indefinite nature. Among these, according to the speaker, are toxic manifestations due to streptomycin to the second and eighth cervical nerves; manifestations to the latter were seen only in patients with renal tuberculosis. Professor Coppo observed an adult with tuberculous meningitis who finally recovered, but in whom streptomycin injected into the cavity had caused a flaccid paraplegia that

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