Recently Avery1 reported a 97% cure rate in a group of 100 patients with enterobiasis (pinworm) who were given a single massive dose (125 mg.) of promethazine (Phenergan) hydrochloride. It is obvious that a therapeutic agent that is this effective, if it is nontoxic, offers great promise not only of curing individual patients but also of eliminating Enterobius infection from families, schools, and institutions for children. A previous study by Sadun and others,2 who treated nine patients with this drug, reported a cure rate of only 44%. In view of Avery's remarkable results and the discrepancy in the results of the two studies, we, in order to verify the results, treated a group of children with promethazine under carefully controlled institutional conditions. A group of children were also treated with pyrathiazine (Pyrrolazote) hydrochloride, a compound closely related to promethazine. To confirm our results, we treated a number of
Brown HW, Chan K, Yolken H. EFFICACY OF PROMETHAZINE AND PYRATHIAZINE AGAINST ENTEROBIASIS. JAMA. 1956;162(11):1049–1051. doi:10.1001/jama.1956.72970280001011
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