† Continued investigations show that infections owing to Micrococcus pyogenes (formerly known as Staphylococcus) often respond to novobiocin. The drug has been used successfully in the treatment of certain cases of bacteremia, soft tissue and bone infections, enterocolitis, urinary infections, post-operative meningitis, and infections of the respiratory tract in which the etiological agent has been M. pyogenes. In this study a dose of 500 mg. orally every six hours was used for moderately severe infections in adults. Side-effects occurred, mostly in the form of allergic dermatitis. The development of resistance to novobiocin by some strains of M. pyogenes has already been observed.
Martin WJ, Heilman FR, Nichols DR, Wellman WE, Geraci JE. NOVOBIOCIN FOR INFECTIONS DUE TO MICROCOCCUS PYOGENES. JAMA. 1956;162(12):1150–1153. doi:10.1001/jama.1956.02970290046011
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