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November 17, 1956


JAMA. 1956;162(12):1178. doi:10.1001/jama.1956.02970290074023

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To the Editor:—  A recent paper by Bell, Hantover, Huebner, and Loosli entitled "Efficacy of Trivalent Adenovirus ( APC ) Vaccine in Naval Recruits" (J.A.M.A.161:1521 [Aug. 18] 1956) has presented preliminary evidence indicating that both a rise in neutralizing antibody and a substantial reduction in the rate of occurrence of adenovirus infections occurred after vaccination with a tissue culture vaccine using types 3, 4, and 7. This program was carried out because evidence of a number of investigations has indicated that adenovirus types 3, 4, and 7 account for a high percentage of acute respiratory disease in military recruits. It is quite possible that this vaccine may be available in the near future through commercial channels to the general practitioner. This letter is to point out that the incidence of adenovirus infections in civilian groups is far lower than that in military recruits. We have recently completed a study of

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